First glimpse of brains retrieving mistaken memories observed — ScienceDaily
Scientists have observed for the first time what it looks like in the key memory region of the brain when a mistake is made during a memory trial. The findings have implications for Alzheimer's...
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Characteristics of the participants in discovery and replication analysesA flowchart of the primary analyses is presented in Fig. 1. In the discovery analysis, the total sample size was 7277 from three cohorts. The mean age...
‘Star-like’ cells display unique activity patterns — ScienceDaily
The way we experience the world occurs due to complex and intricate interactions between neurons in the brain. Now, a study, published 9th February 2022 in Science Advances, suggests that astrocytes -- star-shaped, non-neuronal...
Young child’s brain, not age, determines nap transitions, research suggests — ScienceDaily
Why do some 4- and 5-year-olds still nap like clockwork every afternoon, while other preschoolers start giving up habitual napping at age 3?
It's a question many parents no doubt ponder and one that a...
Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson’s disease and Lewy body dementia
Senescence biomarkers in whole bloodPD patients had significantly lower number of mitochondria (Est. = 62.74, SE = 27.02, df = 1, t = 2.36, p = 0.020, Fig. 1A,) with no significant effect of age (Est. = − 1.506, SE = 1.764, df = 115, t = − 0.857, p = 0.395) and sex (Est. = − 9.237, SE = 16.42, df = 1,...
Early-stage Alzheimer disease: getting trial-ready
Cummings, J., Lee, G., Zhong, K., Fonseca, J. & Taghva, K. Alzheimer’s disease drug development pipeline: 2021. Alzheimers Dement. 7, e12179 (2021).
...
Can a single brain region encode familiarity and recollection?
The human brain has the extraordinary ability to rapidly discern a stranger from someone familiar, even as it can simultaneously remember details about someone across decades of encounters. Now, in mouse studies, scientists at...
Reduced inhibition of hippocampal neurons impairs long-term memory recall in Rett syndrome — ScienceDaily
An exciting study by researchers in the laboratory of Dr. Huda Zoghbi, distinguished service professor at Baylor College of Medicine and director of the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at...
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Investigating metabolic effect modulation by AD risk factorsWe used CSF biomarkers, FDG-PET imaging, and serum metabolomics data on 139 metabolites to investigate metabolic effects in relation to sex and AD and their interaction. Of...
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