Saturday, June 25, 2022

Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based...

Thickness changes in the 10 retinal layers were studied in patients with AD at a very early stage of disease development. We automatically segmented 10 retinal layers, evaluated their thickness at each retinal point...

Individualized prognosis of cognitive decline and dementia in mild cognitive impairment based on plasma...

Study population characteristics (model selection sample)A total of 148 patients with MCI from the Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) cohort for whom all three plasma and CSF biomarker measurements were...

Interactions between sleep disturbances and Alzheimer’s disease on brain function: a preliminary study combining...

1.Prince, M. W. A., Guerchet M., Ali, G., Wu, Y & Prina M. An analysis of prevalence, incidence, cost & trends. Alzheimer’s Disease International; London: 2015. World Alzheimer Report 2015., Available at, https://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf and...

Simultaneous FDG-PET/MRI detects hippocampal subfield metabolic differences in AD/MCI

1.Witter, M. P. & Amaral, D. G. Hippocampal formation. Rat Nerv. Syst. https://doi.org/10.1016/B978-012547638-6/50022-5 (2004).Article  ...

Relationship Between Thyroid Hormone Levels and Regional Cerebral Blood Flow in Alzheimer Disease

Subclinical thyroid disease and even variations in thyroid function within the normal range is associated with cognitive function and a risk of Alzheimer disease (AD). Several studies reported the effect of thyroid hormones on...

Global small vessel disease brain changes predict cognitive decline

Global small vessel disease brain changes predict cognitive decline Read more...

Association Between Gait, Cognition, and Gray Matter Volumes in Mild Cognitive Impairment and Healthy...

Aims: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between...

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan...

Jump to Section1. Introduction2. Methods  2.1. Participants: EMIF-AD Multimodal Biomarker Discovery study  2.2. SOMAscan assay  2.3. Statistical analysis  2.4. Machine learning  2.5. Mendelian randomization3. Results  3.1. Subject demographics  3.2. Proteins significantly associated with amyloid Z-score in both groups  3.3. Multiprotein classifier of...

Insight into underlying causes of seizure disorder in babies — ScienceDaily

Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry. In their study of a mouse model of the disorder,...

Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

All reagents were obtained from Sigma-Aldrich (St. Louis, MO, USA), unless otherwise stated.Intracellular amyloid toxicity in MC65 nerve cellsThe MC65 nerve cells were obtained from Dr. L. W. Jin (UC Davis). The induction of...
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Congratulations UCSF Residency Class of 2022!

The UC San Francisco Department of Radiology and Biomedical Imaging would like to thank our outstanding radiology residents for their dedication,...

Can we save more lives if we let resistant bacteria live? — ScienceDaily

Antibiotic resistance is a ticking bomb under public health. WHO predicts that in 2050 more people will die from infections than from cancer --...

New insights on infant word learning — ScienceDaily

A lot is unknown about how infants begin to connect names with objects, a critical skill for later language development. A new study by...