Alzheimer's Research

Down syndrome is one of the most common genetic conditions in the U.S. and Canada. According to the Centers for Disease Control and Prevention (CDC), about 6,000 babies with Down...

A deep slumber might help buffer against memory loss for older adults facing a heightened burden of Alzheimer's disease, new research from the University of California, Berkeley, suggests. Deep sleep, also known as non-REM slow-wave...

Mouse strainsAll mouse work was approved by the Committee for Animal Care of the Division of Comparative Medicine at Massachusetts Institute of Technology. Hdac1f/f mice were gifted from E.N. Olson23. Hdac1f/f mice were bred...

Gorelick, P. B. et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42, 2672–2713 (2011). An overall guide for practitioners to...

A chest computed tomography (CT) scan finds a lung nodule; what is the significance of that? Brett Elicker, MD, chief of Cardiac & Pulmonary Imaging at the UC San Francisco Department...

Our ability to think, decide, remember recent events and more, comes from our brain's neocortex. Now University of California, Irvine neuroscientists have discovered key aspects of the mechanisms behind these functions. Their findings could...

Advancements in clinical therapies have identified the need for biomarkers of early Alzheimer disease that distinguish the earliest stages of pathology and target those patients who are likely to gain the most benefit. The...

Researchers at the University of Basel have discovered a molecular mechanism that plays a central role in intact long-term memory. This mechanism is also involved in physiological memory loss in old age. Many life forms,...

Jump to Section1. Introduction2. Methods  2.1. Clinical assessment  2.2. Genetic testing  2.3. Image acquisition  2.4. Image processing  2.5. Creation of groups for analysis  2.6. Group comparisons  2.7. Consistency of abnormalities across individuals3. Results  3.1. Mean values across levels of severity  3.2. Frequency of...

The Alzheimer disease 8 (AD8) is a brief informant-based measure that distinguishes individuals with very mild dementia and mild cognitive impairment from those with normal cognition. The aim of this study was to establish...