Thursday, December 9, 2021

A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USAZhijian Yang, Ilya M. Nasrallah, Haochang Shou, Junhao Wen, Jimit Doshi, Mohamad Habes, Guray Erus, Ahmed Abdulkadir, David A. Wolk, Christos Davatzikos, Yong Fan, Vishnu Bashyam, Elizabeth Mamouiran, Randa Melhem, Raymond Pomponio, Dushyant Sahoo, Singh Ashish, Ioanna Skampardoni, Lasya Sreepada, Dhivya...

Unveiling the hidden cellular logistics of memory storage in neurons — ScienceDaily

Exploring the mechanisms involved in sleep-dependent memory storage, a team of University of Michigan (U-M) cellular biologists found that RNAs associated with an understudied cell compartment in hippocampal neurons vary greatly between sleeping and...

Spatial variation of perfusion MRI reflects cognitive decline in mild cognitive impairment and early...

We found that sCoV increased between SCD, MCI and early probable AD groups in GM and in the temporal lobe. As expected, sCoV was negatively correlated with CBF. Overall, our results suggest that sCoV...

Potential new treatment for Alzheimer’s disease would be relatively cheap — ScienceDaily

Researchers at the RIKEN Center for Brain Science (CBS) in Japan have discovered that the protein α-endosulfine (ENSA) is involved in the development of Alzheimer's disease. Studies in mice showed that eliminating this protein...

The effects of molecular crowding and CpG hypermethylation on DNA G-quadruplexes formed by the...

1.Renton, A. E. et al. A Hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72, 257–268 (2011).CAS  PubMed  PubMed Central  ...

Brain region called the anterior thalamus could hold the key for memory function recovery...

The mammalian brain houses a complex network of structures that support memory, and a small region called the anterior thalamus is a critical part of this system. Damage to the mammillothalamic tract (MTT) --...

The Significance of the Recently Published ACC/AHA Chest Pain Guidelines

The American College of Cardiology (ACC)/American Heart Association (AHA) recently published their ACC/AHA Chest Pain Guidelines. This marks the first update to these official clinical practice guidelines in nearly a...

Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration

ParticipantsA total of 56 patients and nine cognitively healthy controls (HC) were enrolled in this study. Patients were recruited from the BioBank Alzheimer Center Limburg (BB-ACL), Maastricht, the Netherlands. Inclusion criteria were an MMSE...
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Exposure to UV rays boost vitamin D, may protect against auto-immune disease — ScienceDaily

Living in sunny locations and spending time outdoors may raise the risk for skin cancer, but a new study led by UC San Francisco...

Cleveland Clinic Research Identifies Sildenafil as Candidate Drug for Alzheimer’s Disease

Newswise — December 6, 2021, CLEVELAND: A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary...