The reliability and validity of DSM 5 diagnostic criteria for neurocognitive disorder and relationship with plasma neurofilament light in a down syndrome population

Application of diagnostic criteria

As shown in Table 2, all diagnostic criteria had good inter-rater reliability, as did clinical judgement. The DSM-5 NCD criteria as a dichotomous variable (NCD or no NCD) had strong inter-rater reliability (k = 0.711), although with a lower inter-rater reliability than ICD-10 (k = 0.866) and slightly lower than clinical judgement (k = 0.723). When the mild and major NCD categories were separated, the inter-rater reliability remained strong for major NCD (k = 0.727) but was only moderate for mild NCD (k = 0.494).

Table 2 Kappa statistic for inter-rater reliability and concurrent validity of each diagnostic criteria and clinical judgement.

Concurrent validity analysis showed substantial concurrence of DSM-5 diagnosis with clinical judgement (k = 0.855), but only moderate concurrence of DSM-5 with ICD-10 or DSM-IV criteria….

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