Alzheimer's Research

1.Rocchi, A., Pellegrini, S., Siciliano, G. & Murri, L. Causative and susceptibility genes for Alzheimer’s disease: a review. Brain Res. Bull. 61, 1–24 (2003).2.Bertram, L., McQueen, M. B., Mullin, K., Blacker, D. & Tanzi,...

This is an observational case–control study to discover differential mRNA expression and enrichment pathways through a genome-wide transcriptome study (GWTS) using microarray technology. For the validation of the significant differentially expressed mRNAs, we performed...

1.DeJesus-Hernandez, M. et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72, 245–256 (2011).2.Majounie, E. et al. Frequency of the C9orf72 hexanucleotide repeat expansion in...

1.Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron. 1989;3:519–26.CAS  PubMed  ...

Scientists have identified that the evolutionary development of human and primate brains may have been similar for communication and memory. Although speech and language are unique to humans, experts have found that the brain's pathway...

ParticipantsParticipants were recruited from the Banner Sun Health Research Institute (BSHRI) from September 2017 to May 2018. Eligible participants from the BSHRI cohort were vetted by the clinic director (KO) to assure eligibility for...

Jump to Section1. Introduction2. Methods  2.1. Model overview  2.2. Data  2.3. Predementia to dementia  2.4. AD dementia  2.5. Community versus institution (AD dementia states)  2.6. Mortality  2.7. Decision-analytic inputs3. Cost-effectiveness analysis: Early intervention in predementia4. Results5. Discussion6. ConclusionsSupplementary dataReferencesThe change in...

AnimalsAll mouse work was approved by the Committee for Animal Care of the Division of Comparative Medicine at the Massachusetts Institute of Technology. 5XFAD (Tg 6799) breeding pairs were acquired from the Mutant Mouse...

ParticipantsIn this cross-sectional study, we included N = 121 participants (Fig. 5; Table 1 for demographic description) from the study Remote Assessment of Disease and Relapse – Alzheimer’s Disease (RADAR-AD). Inclusion criteria were community-dwelling adults older...

Virginia Tech researchers discovered a new function for a common protein in the brain -- a development that sheds new light on the mysteries of the mind and holds promising implications for the treatment...