Mouse strains
All mouse work was approved by the Committee for Animal Care of the Division of Comparative Medicine at Massachusetts Institute of Technology. Hdac1f/f mice were gifted from E.N. Olson23. Hdac1f/f mice were bred with Nestin-Cre transgenic mice24 to generate Hdac1 brain-specific conditional knockout (Hdac1 cKO) mice. 5XFAD mice were obtained from Jackson Laboratory (JAX ID# 34840), and were crossed with Hdac1 cKO mice to generate Hdac1 cKO; 5XFAD (compound transgenic) mice. Aged C57BL/6J mice were obtained from National Institute on Aging. Two- to three-month-old male mice were used as young group, and 13- to 17-month-old male mice were used as aged group. Mice were housed in groups of three to five animals on a standard 12 h light/12 h dark cycle, temperature (24 °C), and humidity (45%) with food and water available ad libitum. All experiments were performed…
