Missed and Delayed Diagnosis of Dementia in Primary Care: Prevalence and Contributing Factors
Dementia is a growing public health problem for which early detection may be beneficial. Currently, the diagnosis of dementia in primary care is dependent mostly on clinical suspicion on the basis of patient symptoms...
Newly Published Research Reports an Important Discovery About Abdominal Aortic Aneurysms (AAAs)
Abdominal aortic aneurysm (AAA) disease is common; approximately 200,000 people in the U.S are diagnosed each year. They occur when the walls of the aorta bulge or dilate. If the...
Willingness to Undergo a Risky Treatment to Improve Cognition Among Persons With Cognitive Impairment...
Objective:
To evaluate determinants of willingness to accept a treatment to return memory to normal among persons with cognitive impairment who received an amyloid positron emission tomography (PET) scan and their care partner and...
Vulnerability of Husband and Wife Caregivers of Alzheimer Disease Patients to Caregiving Stressors
Summary:
This study assessed relationships between problem behaviors in 199 Alzheimer Disease patients and vulnerability factors in the well being and emotional health of their spouse caregivers. Among caregiver wives and the younger caregiver husbands...
Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal...
1.Jack, C. R. Jr. et al. NIA-AA Research Framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 14, 535–562 (2018).2.Blennow, K., Hampel, H., Weiner, M. & Zetterberg, H. Cerebrospinal fluid and plasma biomarkers...
Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of...
Generation of Trem2
R47H rats carrying humanized App alleles (App
h/h)F0-Trem2R47H rats were crossed to Long-Evans rats to generate F1- Trem2R47H/w rats. These crossings were repeated four more times to obtain F5-Trem2R47H/w rats. The probability that...
Another step forward in blood-based diagnostics for Alzheimer’s disease
Competing interests
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Hyper BOLD Activation in Dorsal Raphe Nucleus of APP/PS1 Alzheimer’s Disease Mouse during Reward-Oriented...
1.Ritchie, K. & Lovestone, S. The dementias. Lancet 360, 1759–1766 (2002).2.Bidzan, L., Bidzan, M. & Pąchalska, M. Aggressive and impulsive behavior in Alzheimer’s disease and progression of dementia. Med. Sci. Monit. 18, 182–189 (2012).3.Rochat,...
A New Deep Learning Approach for Image Analysis of Osteoarthritis
Hip osteoarthritis can be a painful and debilitating condition. Unfortunately, osteoarthritis is a degenerative disease with no cure, as of yet. A long term research goal of the Musculoskeletal Quantitative...
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Investigating metabolic effect modulation by AD risk factorsWe used CSF biomarkers, FDG-PET imaging, and serum metabolomics data on 139 metabolites to investigate metabolic effects in relation to sex and AD and their interaction. Of...
Latest article
Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...