Alzheimer's Research

Cohort description and sequencingBriefly, sequencing in NIMH was performed by Illumina HiSeq 2000. Alignment to the human reference genome (GRh37) was done with bwa-mem50 (v0.7.7, default parameters). Variants were jointly called for each family...

Abstract: Care-giver health-related quality-of-life (QoL) as a predictor of nursing-home placement of family-member patients with dementia was evaluated (using the SF-36 questionnaire) in 181 care providers (78% females; mean age 63 years) at the start...

Palm Beach, FL, March 11, 2019 – The Alzheimer’s Drug Discovery Foundation (ADDF) honored photographer, humanitarian and philanthropist Judy Glickman Lauder at its third annual Hope on the...

Patient navigators are becoming familiar faces in hospitals across the country. They are individuals with professional medical, legal, financial, or administrative experience who act as an advocate and liaison for...

Clonal FAD hNPCs generated by single cell sortingHeterogeneous FAD hNPCs were generated as previously described by expressing lentiviral DNA constructs harboring APPSL and/or PS1ΔE9 (Supplementary Table 1)21,22. To obtain clonal FAD hNPCs, heterogeneous FAD hNPCs were...

Purpose: Subjective memory complaints (SMCs) have been shown to be associated with lower neuropsychological test scores cross-sectionally. However, it remains unclear whether such findings hold true for African American (AA) older adults. Methods: Baseline visit...

MiceHuman APOE targeted replacement mice were first developed by Sullivan et al.28,29 and were acquired from Dr. Sullivan, or from Taconic Biosciences. All mice used in this study were treated in accordance with the...

Background: Relationships between brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF-1), aldosterone, and cognition in aging were evaluated in the population-based Epidemiology of Hearing Loss Study (1993 to present). Methods: Beginning in 1998 to 2000,...

Morphing face discriminationIn the morphing face discrimination task, half of the trials were physically the same (the 0% morph level) and half were different (all other morph levels); therefore, we adopted the signal detection...