Remembering Marcia J. McCowin, MD
1952 - 2020
Marcia J. McCowin, M.D. passed away peacefully at her home on April 26, 2020 after a long battle with multiple myeloma.
Dr. McCowin received her undergraduate degree from the University...
Disease-associated astrocytes in Alzheimer’s disease and aging
1.Keren-Shaul, H. et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell 169, 1276–1290.e17 (2017).2.Strooper, B. & Karran, E. The cellular phase of Alzheimer’s disease. Cell 164, 603–615 (2016).3.Baruch, K....
Progressive Changes in Hippocampal Resting-state Connectivity Across Cognitive Impairment: A Cross-sectional Study From Normal...
We investigate the changes in functional connectivity of the left and right hippocampus by comparing the resting-state low-frequency fluctuations in the blood oxygen level-dependent signal from these regions with relation to Alzheimer disease (AD)...
Retrospective and Prospective Data Collection Compared in the Dutch End of Life in Dementia...
Studying end of life in dementia patients is challenging because of ill-defined prognoses and frequent inability to self-report. We aim to quantify and compare (1) feasibility and (2) sampling issues between prospective and retrospective...
Liposomal drug delivery of Aphanamixis polystachya leaf extracts and its neurobehavioral activity in mice...
MaterialsThe leaves of the plant Aphanamixis Polystachya were collected from Dinajpur, Bangladesh. All solvents used in this study were purchased from Sigma Aldrich, India and was of analytical grade. Phospholipid was extracted from chicken...
Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
Study populationAmong a study population of 6,595,271 adults, 272,657 had a new diagnosis of dementia during the follow-up period (Fig. 1). The mean duration of follow-up was 7.6 years, and the overall incidence of dementia...
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian...
Objective:
Neuroinflammation may play an important role in the pathogenesis and progression of Alzheimer disease (AD). The aim of the present study was to detect whether increased inflammatory activity at baseline could predict cognitive...
Help-Seeking for Dementia: A Systematic Review of the Literature
Background:
Help-seeking (HS) for dementia presents a great challenge, especially because a timely and appropriate HS process might be associated with better outcomes for the person with dementia, their caregivers, and society. A clear...
Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects...
Cellular culture and transfectionMurine Neuroblastoma N2a cells were stably transfected with pcDNA 3.1 Zeo + vector with resistance to Zeocin. 1 µg of 4 different plasmids: Mock (empty vector), human PS1WT, PS1E280A and PS1Δ9 were...
Distinct BOLD variability changes in the default mode and salience networks in Alzheimer’s disease...
ParticipantsWe studied 124 AD, 103 aMCI, and 49 HC from an ongoing project, recruited from memory clinics in the National University Hospital, Saint Luke’s Hospital and nearby communities52,53. Diagnoses were made by psychologists, neurologists,...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...