The Metric Properties of Zarit Caregiver Burden Scale: Validation Study of a Chinese Version
Purpose
To evaluate the Chinese version of the Zarit Burden Interview (ZBI) as an instrument for measuring strain in Chinese caregivers of elderly people with dementia.
Design and Methods
The objective of the present study...
Relationship Between Thyroid Hormone Levels and Regional Cerebral Blood Flow in Alzheimer Disease
Subclinical thyroid disease and even variations in thyroid function within the normal range is associated with cognitive function and a risk of Alzheimer disease (AD). Several studies reported the effect of thyroid hormones on...
The Efficacy of Nonpharmacological Treatment for Dementia-related Apathy
Objective
To determine the usefulness of a formal, structured, nonpharmacological treatment for apathetic dementia patients.
Patients and Methods
A controlled, cross-over, randomized, simple-blind, multicentre clinical trial. A total of 146 institutionalized or day care dementia...
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s...
AnimalsMouse experiments were performed with the approval of the Massachusetts General Hospital Animal Care and under the guidelines of Institutional Animal Care and Use Committees (IACUC, protocol #2004N000047) for the use of experimental animals....
Longitudinal Trajectories of Awareness in Early-stage Dementia
Although it is often assumed that awareness decreases as dementia severity increases, there is limited evidence regarding changes in awareness over time. We examined awareness in 101 individuals with early-stage dementia (PwD) and their...
Risk factor for Alzheimer’s disease breaks the blood–brain barrier
The best-known hallmarks of Alzheimer’s disease are clumps of misfolded...
The Impact of Dementia Severity on Caregiver Burden in Frontotemporal Dementia and Alzheimer Disease
Caregiver burden is greater in frontotemporal dementia (FTD) than in Alzheimer disease (AD). However, little is known of the impact of the 3 main clinical variants of FTD— behavioral-variant frontotemporal dementia (bvFTD), semantic dementia...
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
1.Wardlaw, J. M. et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 12, 822–838 (2013).2.Kapasi, A., DeCarli, C. & Schneider, J. A. Impact of...
Identifying a subtype of Alzheimer’s disease characterised by predominant right focal cortical atrophy
ParticipantsWe retrospectively collected data from 226 patients with amyloid PET-positive AD and 17 patients with amyloid PET-positive lvPPA. Experienced neurologists evaluated the participants based on their clinical symptoms and reviewed medical histories, neuropsychological test...
The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin
Peripherally-derived myeloid cells rapidly repopulate the microglia-depleted brain and adopt a microglia-like phenotype in wild type miceTo examine morphology and functionality of endogenous microglia and PDMCs in the non-diseased brain environment we crossed CX3CR1-GFP+/−...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...