Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptake
Sperling, R. A. et al. Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers. Dement. 7, 280–292 (2011).PubMed
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What does the sleeping brain think about? — ScienceDaily
We sleep on average one third of our time. But what does the brain do during these long hours? Using an artificial intelligence approach capable of decoding brain activity during sleep, scientists at the...
The Carer Assessment of MedicaTion Management GuidanCe for People With Dementia at Hospital Discharge...
Purpose:
The Carer Assessment of medicaTion management guidanCe for people with dementia at Hospital discharge (CATCH) tool was developed to examine the carer’s experiences of medication management guidance delivery at discharge. This study explored...
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Study populationsAIBL: we selected 216 cases and 631 controls (participants with mild cognitive impairment were regarded as controls) with genotype information from the Australian Imaging, Biomarker & Lifestyle Flagship Study (Table 1). We removed SNPs...
How novelty triggers neural mechanisms that facilitate flexible strategy encoding — ScienceDaily
A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain's hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies. The study, published...
Gene Therapy Trial for Parkinson’s Disease Uses Intra-Operative MRI-Guided Monitoring
Parkinson’s is a disease that develops in part of the midbrain known as the substantia nigra when the cells producing dopamine start to die off. (Dopamine is a neurotransmitter that...
Understanding of novel functional roles can advance research in Alzheimer’s disease, other learning and...
A research team led by University of California, Irvine has discovered new neural circuits that regulate spatial learning and memory in the brain's hippocampal formation. The team identified novel functional roles of new circuit...
Tatiana Kelil, MD Appointed to 2020 Class of John A. Watson Faculty Scholars
Tatiana Kelil, MD, has been selected as a John A. Watson Faculty Scholar for the 2020-21 academic year. Dr. Kelil is an assistant professor of clinical radiology in the UC...
New study reports that cognitive decline is not due to the Alzheimer’s hallmark —...
Depression in elderly people can include symptoms such as memory loss, making it hard to distinguish from the early stages of Alzheimer's disease and other types of dementia. A signature of Alzheimer's is accumulation...
Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s...
Participant characteristicsParticipant characteristics are presented in Table 1. The AD group consisted of 115 individuals diagnosed as AD without CVD and 36 individuals diagnosed as AD with CVD.Table 1 Participants characteristics.
Parameters that were not...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...