Memory trace interference impairs recall in a mouse model of Alzheimer’s disease
1.Semon, R. W. The Mneme (G. Allen & Unwin, 1921).2.Josselyn, S. A., Köhler, S. & Frankland, P. W. Finding the engram. Nat. Rev. Neurosci. 16, 521–534 (2015).CAS
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These oldest-old are also less susceptible to other types of neurodegenerative changes — ScienceDaily
A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer's patients, however,...
Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse...
Neurofibrillary pathology in aged APPswe/PS1ΔE9 miceFresh-frozen brain sections from APPswe/PS1ΔE9 transgenic (TG) mice and their wild-type (WT) counterparts were processed along with human brain sections for the detection of neurofibrillary alterations with the Gallyas...
Mathew Knowles’ Breast Cancer Diagnosis Brings Male Breast Imaging to the Forefront
Earlier this month, Mathew Knowles, the father and former manager of Beyoncé and Solange, announced that he received treatment for breast cancer. Breast cancer in men is rare, representing less...
UCSF Radiology MI&T Experts Review Dosimetry in Radionuclide Therapy
A team of faculty and fellows from the Molecular Imaging and Therapeutics (MI&T) section at the UC San Francisco Department of Radiology and Biomedical Imaging recently wrote a review on dosimetry in...
Association of gout with brain reserve and vulnerability to neurodegenerative disease
Kuo, C.-F., Grainge, M. J., Zhang, W. & Doherty, M. Global epidemiology of gout: prevalence, incidence and risk factors. Nat. Rev. Rheumatol. 11, 649–662 (2015).Article
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Rapidly progressive dementias — aetiologies, diagnosis and management
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn (American Psychiatric Association, 1994).Geschwind, M. D. Rapidly progressive dementia. Continuum 22, 510–537 (2016).PubMed
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An Alzheimer’s-disease-protective APOE mutation
An Alzheimer’s-disease-protective APOE mutation
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Gene mutation linked to learning deficits in ‘Clueless’ mice — ScienceDaily
A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS. The novel mutation decreases the...
New Strategies for Treating Parkinson’s Disease in Veterans: Advances in Diagnosis, Treatment and Prevention
Parkinson's Disease (PD) is a chronic and progressive movement disorder that results from the degeneration of dopamine-producing neurons in the brain. This leads to a range of motor symptoms, including...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...