Alzheimer's Research

Jack, C. R. et al. NIA-AA research framework: Toward a biological definition of Alzheimer’s disease. Alzheimer’s Dement. 14, 535–562 (2018).Article  ...

Clinico-pathologic groupsThis research was ethically approved by the University of Washington Institutional Review Board (IRB) and the Stanford University IRB. All study cohort participants provided informed consent under protocols approved by these IRBs. Sex...

Normal aging leads to frontocortical atrophy. The degree to which this complicates the use of frontotemporal atrophy as a diagnostic criterion for the frontotemporal dementias (FTDs) has not been reported. The present case-control study...

On April 13-14th 2023, the HMTRC celebrated its 11th year as a center and its annual Workshop continues to have a national and global impact on the advancement of hyperpolarized...

Livingston, G. et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet 396(10248), 413–446. https://doi.org/10.1016/S0140-6736(20)30367-6 (2020).Article  ...

2020 Alzheimer’s disease facts and figures. Alzheimers Dement, https://doi.org/10.1002/alz.12068 (2020).Swanson, C. J. et al. A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Abeta protofibril antibody. Alzheimers Res....

Reagents and materialsHeavy labeled peptides (Thermo PEPotec SRM Peptide Libraries; Grade 2; crude as synthesized), trypsin, mass spectrometry grade, trifluoroacetic acid (TFA), foil heat seals (AB-0757), and low-profile square storage plates (AB-1127) were purchased...

Study populationData were from the NHANES, a large, nationally representative cross-sectional survey and physical examination conducted in 2-year cycles, assessing the health and nutritional status of the civilian, noninstitutionalized United States population. Details of...

ParticipantsStudy materials were collected from digital clock drawing consortium data between the University of Florida (UF) and New Jersey Institute for Successful Aging (NJISA), Memory Assessment Program, School of Osteopathic Medicine, Rowan University. The...

A deep slumber might help buffer against memory loss for older adults facing a heightened burden of Alzheimer's disease, new research from the University of California, Berkeley, suggests. Deep sleep, also known as non-REM slow-wave...