The development of an automated machine learning pipeline for the detection of Alzheimer’s Disease
In this proof-of-concept study, we demonstrate that the quantitative analysis of brief (5 min), resting-state EEGs in the frequency domain using a portable, low density (14 channels) montage reveals significant differences between AD patients and...
Effects of different virtual reality technology driven dual-tasking paradigms on posture and saccadic eye...
Langa, K. M. & Levine, D. A. The diagnosis and management of mild cognitive impairment a clinical review. JAMA J. Am. Med. Assoc. 312, 2551–2561. https://doi.org/10.1001/jama.2014.13806 (2014).Article
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Using a neural network model, University of Pennsylvania neuroscientist Anna Schapiro and colleagues found...
What role do the stages of sleep play in forming memories? "We've known for a long time that useful learning happens during sleep," says University of Pennsylvania neuroscientist Anna Schapiro. "You encode new experiences...
Young child’s brain, not age, determines nap transitions, research suggests — ScienceDaily
Why do some 4- and 5-year-olds still nap like clockwork every afternoon, while other preschoolers start giving up habitual napping at age 3?
It's a question many parents no doubt ponder and one that a...
People have more memories associated with older media, appreciate content tied to memory more...
That song really takes me back.
We've all heard a song or seen a movie that brings back a memory or reminds us of an earlier time. A new study from the University of Kansas...
Reactivating memories triggers electrical activity signifying improvement in storage — ScienceDaily
A new study looks deep inside the brain, where previous learning was reactivated during sleep, resulting in improved memory.
Neuroscientists from Northwestern University teamed up with clinicians from the University of Chicago Epilepsy Center to...
Scientists from Japan show how the intranasally delivered oxytocin derivative could be used to...
Alzheimer's disease (AD), characterized by an accumulation of β-amyloid protein (Aβ) in brain tissue, is a leading cause of dementia. Researchers at Tokyo University of Science have previously reported on the oxytocin-induced reversal of...
Transcriptional targets of senataxin and E2 promoter binding factors are associated with neuro-degenerative pathways...
Du, R. et al. Early-life famine exposure and risk of cardiovascular diseases in later life: Findings from the REACTION study. J. Am. Heart Assoc. 9, e014175 (2020).Article
PubMed
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Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials
Study designOur goals were to characterize clinical trials across major neurodegenerative disease indications, identifying correlations and temporal trends, particularly with regards to disease stages and molecular targets of drugs. We chose ClinicalTrials.gov as a...
Mitochondrial biogenesis, telomere length and cellular senescence in Parkinson’s disease and Lewy body dementia
Senescence biomarkers in whole bloodPD patients had significantly lower number of mitochondria (Est. = 62.74, SE = 27.02, df = 1, t = 2.36, p = 0.020, Fig. 1A,) with no significant effect of age (Est. = − 1.506, SE = 1.764, df = 115, t = − 0.857, p = 0.395) and sex (Est. = − 9.237, SE = 16.42, df = 1,...