Alzheimer's Research

Human samplesHuman frozen postmortem tissues were obtained from the Mayo Clinic Brain Bank (Jacksonville, FL USA). Notably, 3 of the 12 control brains were obtained via the Einstein Aging Study. All brains were acquired...

An LSU Health New Orleans research study led by Siqiong June Liu, PhD, Professor of Cell Biology and Anatomy, has found that cerebellar inhibitory interneurons are essential for fear memory, a type of emotional...

AnimalsTg-APPswe/PS1dE9 (Tg-APP/PS1) mice, which overexpress mutant forms of human amyloid precursor protein (APP) and presenilin-1 (PS1) genes, were maintained as C57BL6 × C3H F1 hybrids as previously described22,32. After weaning, male and female mice were separately...

McKeith, I. et al. Dementia with Lewy bodies. Lancet Neurol. 3, 19–28 (2004).Article  ...

Objectives This study estimated the prevalence of diagnosed dementia among Indiana Medicaid beneficiaries in 2004. The dependence of prevalence estimates upon use of several patient selection criteria to identify patients with dementia also was...

Gaugler, J. et al. Alzheimer’s disease facts and figures. Alzheimers Dementia 18(4), 700–789 (2022).Article  ...

New research from Rice University finds that antidepressants may actually reduce negative memories in individuals suffering from depression while improving overall memory function. The study, "Perceived antidepressant efficacy associated with reduced negative and enhanced neutral...

A secure digital platform was developed to integrate in-home IoT and remote monitoring technologies to collect routine physiological, sleep, movement, and ambient data11.Digital markersDigital markers are measurable physiological and in-home movement data gathered and...

After adjustment for other CV risk factors or diseases, diabetes, stroke, HF and AF remained significantly associated with an increased dementia risk in all aged groups studied. The strength of these associations decreased with...

In moderate-to-severe Alzheimer disease (AD), there are significant losses of activities of daily living (ADL). In a recent prospective, randomized, placebo-controlled trial, memantine treatment lessened the overall functional decline in AD patients already on...