pLG72 levels increase in early phase of Alzheimer’s disease but decrease in late phase
1.Levey, A., Lah, J., Goldstein, F., Steenland, K. & Bliwise, D. Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer’s disease. Clin. Ther. 28, 991–1001 (2006).2.Lin, C. H.,...
A novel kit for early diagnosis of Alzheimer’s disease using a fluorescent nanoparticle imaging
Physical and binding properties of the diagnostic kitStudies have been conducted to develop diagnostic indices for the early detection of AD35. Our fluorescent nanoparticle complex for detecting miRNA and antigens for the early detection...
Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology
SubjectsThe study cohort included 27 HC, 26 patients with MCI, and 27 patients with dementia recruited at Osaka University Hospital. Physicians specialized in geriatric medicine and dementia assessed all participants. All subjects underwent standard...
Spatial analysis of thickness changes in ten retinal layers of Alzheimer’s disease patients based...
Thickness changes in the 10 retinal layers were studied in patients with AD at a very early stage of disease development. We automatically segmented 10 retinal layers, evaluated their thickness at each retinal point...
UCSF Radiology Introduces A New Molecular Imaging and Therapeutics (MI&T) Clinical Section
The past decade has seen a number of new molecular diagnostic and therapeutic imaging agents enter clinical practice, especially in oncology, cardiology, and the neurosciences. The UC San Francisco Department...
The Alzheimer’s Disease Exposome – Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
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Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study
Fig. 2Baseline gait domains: associations with subsequent decline in Global Cognition and incident dementia. (A) Association of baseline independent gait domains with subsequent decline in Global Cognition. For all gait domains, higher scores correspond with...
Ageing as a risk factor for neurodegenerative disease
1.Rose, M. R. Adaptation, aging, and genomic information. Aging 1, 444–450 (2009).2.Carmona, J. J. & Michan, S. Biology of healthy aging and longevity. Rev. Invest. Clin. 68, 7–16 (2016).3.Alzheimer’s Association. 2018 Alzheimer’s disease facts...
Cognitive function after surgery with regional or general anesthesia: A population-based study
When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of −0.041, P = .011) and GA...
Differential expression of microRNAs in Alzheimer’s disease brain, blood, and cerebrospinal fluid
Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta-analyses. Twenty-five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10−4) in brain, cerebrospinal fluid, and blood-derived specimens, respectively,...