Insulin Resistance Syndrome and Alzheimer Disease: Pathophysiologic Mechanisms and Therapeutic Implications
Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations, reduces insulin activity, and reduces brain insulin levels. The insulin resistance syndrome and...
A Call for Changes After Study Finds Internal Medicine Residency Program Directors Misinterpret Leave...
Parental leave policies are a frequent topic in the news, including in the field of internal medicine. Kirti Magudia, MD, PhD, a T32 scholar and clinical fellow in the Abdominal...
Bacterial DNA promotes Tau aggregation
1.Frost, B. & Diamond, M. Prion-like mechanisms in neurodegenerative diseases. Nature Reviews Neuroscience 11, 155–159 (2009).2.Olanow, C. W. & Prusiner, S. Is Parkinson’s disease a prion disorder? Proceedings of the National Academy of Sciences...
Karen Ordovas, MD, MAS Discusses the Benefits of Cardiac MRI
Cardiovascular magnetic resonance imaging (CMR) or cardiac MRI is a medical imaging technology that provides a noninvasive diagnostic assessment of the cardiovascular system. Cardiac MRI helps to achieve improved diagnosis...
Research Issues for Minority Dementia Patients and Their Caregivers: What Are the Gaps in...
Summary:
This article highlights the current state of dementia research in ethnic minority populations. Studies are sparse, and an increased effort to recruit and retain minorities for dementia studies is required to properly treat and...
Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers
Test description and reagents compositionThe e4Risk test is a CE-marked and commercially available immunoturbidimetry test composed of two ready-to-use reagents (R1 and R2), one calibrator, and positive and negative controls, which are used as...
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in...
The regularized OMT (rOMT) problem60 considers the minimization of the energy functional$$ {mathcal R} =,{int }_{0}^{1}mathop{int }limits_{{mathfrak{X}}}frac{1}{2}mu (t,x)||v(t,x)|{|}^{2}dxdt$$
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Research Looks at the Predictive Value of Non-Contrast Head CT with Negative Findings in...
In the emergency department (ED), non-contrast head CTs are routinely acquired for patients with neurologic symptoms. Anecdotally, non-contrast head CTs performed in patients with prior negative findings on CTs performed...
T.J. Oshie of the Washington Capitals Hosts Broomball Fundraiser to Benefit the Alzheimer’s Drug...
T.J. Oshie, in partnership with WARROAD, the Super Service Challenge, and NT Concepts, hosted a broomball tournament on Wednesday, February 5th at MedStar Capitals Iceplex, which raised over...
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling
1.Govindpani, K. et al. Vascular dysfunction in alzheimer’s disease: a prelude to the pathological process or a consequence of it? J. Clin. Med. 8, 651 (2019).2.Jefferies, W. A. et al. Adjusting the compass: new...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...