Friday, August 12, 2022

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

1.Lambert, J. C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat. Genet. 45, 1452–1458 (2013).2.Alzheimer’s Association. 2018 Alzheimer’s disease facts and figures. Alzheimers Dement. 14, 367–425 (2018).3.Serrano-Pozo,...

Alzheimer Disease & Associated Disorders

Wells, Jennie L., BSc, MSc, MD, FACP, FRCPC, CCRP*,†; Pasternak, Stephen H., MD, PhD, FRCPC†,‡,§Early onset Alzheimer disease (EOAD) is a neurodegenerative dementing disorder that is relatively rare (<1% of all Alzheimer cases). Various...

CT Lung Cancer Screening: How Vivid Images are Reducing Lung Cancer Deaths

A chest computed tomography (CT) scan finds a lung nodule; what is the significance of that? Brett Elicker, MD, chief of Cardiac & Pulmonary Imaging at the UC San Francisco Department...

Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging

Over a 3.5-year follow-up, participants with BF showed an increased risk of overall dementia (hazard ratio : 2.16, 95% confidence interval :1.07-4.37), particularly vascular dementia (VaD) (HR: 3.21, 95% CI: 1.05-9.75). Similarly, over a...

A BRAND NEW DAY IS BORN

Posted on September 26, 2017 by Norm McNamara A BRAND NEW DAY IS BORN ...

Thirteenth Connoisseur’s Dinner Recognizes Core Funders of Its Diagnostics Accelerator

On Thursday, May 30, the Alzheimer's Drug Discovery Foundation (ADDF) held its Thirteenth Annual Connoisseur's Dinner at Sotheby's in New York City. Hosted by nine-time Emmy award-winning journalist...
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Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease

Participant characteristicsThe present study was performed in the ALFA+ cohort, a nested longitudinal study from the ALFA (for ALzheimer’s and FAmilies) study16. The ALFA...

Protective effect of apolipoprotein E epsilon 3 on sporadic Alzheimer’s disease in the Chinese...

Study characteristicsAmong the 2134 articles retrieved from the databases, 116 articles were finally screened: 96 Chinese articles (Supplementary) and 20 English articles17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36. The articles...

Banana peels make sugar cookies better for you — ScienceDaily

Banana peels aren't always destined for the trash or compost anymore. They're making their way onto people's plates, replacing pork in "pulled peel" sandwiches...