Alzheimer's Research

Priyanka Jha, MBBS, associate professor of clinical radiology, recently led a team of investigators who studied the diagnostic performance of the Ovarian-Adnexal Reporting and Data System (O-RADS). They found that...

Anytime we venture into a new place, our brain's built-in GPS immediately kicks in and begins to form a spatial map of our surroundings. Over days and even weeks, this map may be solidified...

New research has revealed how the tau protein, a critical element in the formation of Alzheimer's disease, is also involved in normal learning processes in the healthy brain -- potentially providing a focal point...

Brain cells with the same "birthdate" are more likely to wire together into cooperative signaling circuits that carry out many functions, including the storage of memories, a new study finds. Led by researchers from NYU...

Conceptual introduction of the MultiNODEsMultiNODEs represent an extension of the original NODEs framework14 that overcomes the limitations of its predecessor such that an application to incomplete datasets consisting of both static and time-dependent variables...

Ossenkoppele, R. et al. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain 139, 1551–1567 (2016).PubMed  PubMed Central  Article  ...

Study datasetsOur meta-analysis of blood samples included a total of 1284 DNA methylation samples (427 AD cases, 857 cognitive normals) from two large independent AD EWAS, the ADNI14 and the AIBL16 studies. The ADNI...

Predictors of unfavourable outcomes in iNPH patientsIn the analyses targeting all participants, we showed that the presence of hypertension, more severe urinary dysfunction evaluated by the iNPHGS urination subscore, relatively smaller lateral ventricles for...

ParticipantsA total of 19 patients in the mild phase of AD (Clinical Dementia Rating = 1) and 19 controls, recruited from the community with no evidence of cognitive impairment or other relevant pathologies, were enrolled in...

World Health Organaization. Dementia. 2021. https://www.who.int/news-room/fact-sheets/detail/dementia.Cabinet Office GoJ. Situation on ageing: current state and trends on the elderly and their environment. Annual Report on the Ageing Society. 2017. https://www8.cao.go.jp/kourei/whitepaper/w-2017/zenbun/29pdf_index.html.Prince M, Bryce R, Albanese E,...