Alzheimer's Research

Background: E2027 is a novel, highly selective and potent inhibitor of phosphodiesterase9 (PDE9) being evaluated as a treatment for dementia with Lewy bodies. Methods: Phase 1, randomized, double-blind, single ascending dose (SAD, n=96) and multiple...

Older adults who play digital puzzle games have the same memory abilities as people in their 20s, a new study has shown. The study, from the University of York, also found that adults aged 60...

How can the amazing abilities of our memory be explained on the basis of brain anatomy? It is known that different brain functions are anchored in different areas and structures of the brain. For...

Jahn, H. Memory loss in Alzheimer’s disease. Dialogues Clin. Neurosci. 15, 445–454 (2013).Article  PubMed  PubMed Central  ...

Ou, S. H., Wu, F., Harrich, D., Garcia-Martinez, L. F. & Gaynor, R. B. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence...

Cairns, N. J. et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol. 114, 5–22 (2007).Article  PubMed  ...

Researchers have long thought that rewards like food or money encourage learning in the brain by causing the release of the "feel-good" hormone dopamine, known to reinforce storage of new information. Now, a new...

Social learning is typically thought to be most beneficial when the environments in which individuals live change quite slowly – they can safely learn tried and tested information from one another and it does...

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.This is a summary of: Johnson, E. C. B. et al. Cerebrospinal fluid proteomics define the natural history...

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity. The insulin super-family of hormones, including insulin, insulin-like growth factor 1 (IGF1), and insulin-like...