Editorial Board – Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
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$2.5 Million in New Funding Exemplifies ADDF’s Strategy
The Alzheimer’s Drug Discovery Foundation (ADDF) announces $2.5 million in new funding, which reflects the comprehensive nature of our strategy to prevent and treat Alzheimer’s disease. These 10...
Space-like 56 Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype...
Despite knowledge that spaceflight causes significant sex-dependent physiological changes in astronauts, the sex-dependent differences in neurobehavioural responses to HZE radiation are still relatively unexplored. This issue is not unique to the field of radiation...
Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes...
Jump to Section1. Introduction2. Methods and materials 2.1. Participants 2.2. Collection of neuronal-derived exosomes from blood 2.3. Transmission electron microscopy 2.4. Western blot 2.5. Collection of CSF 2.6. Protein measurements 2.7. Statistical analysis3. Results 3.1. Participant characteristics 3.2. Confirmation of exosomal collection 3.3. Levels...
New Investments Fund Research Ranging from Novel Treatments for Postoperative Cognitive Dysfunction
The Alzheimer's Drug Discovery Foundation (ADDF) announces seven new investments, including four clinical trials, two novel drug programs, and a prevention program which reflects the comprehensive nature of...
Genetic variation across RNA metabolism and cell death gene networks is implicated in the...
This study utilized summary statistics of the phase-1 GWAS data from the International FTD-Genomics Consortium (IFGC), comprised of 2,154 clinically diagnosed FTD spectrum cases and 4,308 controls and a total of 6,026,384 SNPs. Of...
Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in...
Immunotherapeutic approaches targeting amyloid β (Aβ) protein and tau in Alzheimer's disease and α-synuclein (α-syn) in Parkinson's disease are being developed for treating dementia with Lewy bodies. However, it is unknown if single or...
New Coalition of Philanthropists Including Bill Gates, Leonard Lauder Commit More Than $30 Million
Philanthropist Bill Gates and the Alzheimer's Drug Discovery Foundation (ADDF) co-founder Leonard Lauder have announced a new initiative, Diagnostics Accelerator, to develop novel biomarkers for the early detection...
Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in...
Ethics statementThe research involving animals was authorized by the Italian Ministry of Health, Department of Veterinary Public Health, Nutrition and Food Safety, Directorate General of Animal Health and Veterinary Medicine, as required by Italian...
Mild cognitive impairment has similar alterations as Alzheimer’s disease in gut microbiota
Fig. 1The α-diversity and β-diversity indices of the fecal and blood microbiota in patients with AD and MCI and normal controls. (A-D) Box plots depict differences in the fecal α-diversity indices according to the Chao...
