A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies
Fig. 1Descriptive meta-analysis from the related literature of the available amyloid-, tau-, and neuroinflammation-PET findings in proteinopathies. Color gradients index magnitude of alteration. Abbreviations: MSA, multiple system atrophy; PD, Parkinson's disease; PDD, Parkinson's disease and dementia;...
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells
Cells and cultureHT22 is a mouse hippocampal neuronal cell line28, and cells were cultured in Dulbecco’s modified Eagle medium (DMEM) supplemented with 15% heat-inactivated fetal bovine serum (FBS) and antibiotics at 37 °C under 5%...
Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study...
Increased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio...
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
AD causal variants in the PVRL2 and APOC1 regionsWe recently reported a WGS study of AD in the mainland Chinese population (n = 1172; Supplementary Table 1), in which multiple variants located in APOE and the surrounding...
Bioinformatics strategy to advance the interpretation of Alzheimer’s disease GWAS discoveries: The roads from...
Fig. 2Enhancer-promoter interaction plot for the >1 Mb defined BIN1 LOAD-GWAS region, tagged by SNP rs6733839. (A) Line plot of the interaction frequency for Hi-C reads in the hippocampus, anchoring point at chr2:127,893,000 (5′ end of...
Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface
Fibril formation and characterization of Aβ20–34 peptidesSix early-onset hereditary Alzheimer’s mutations and two PTMs, including the isomerized Asp23, are localized in the Aβ 1–42 peptide to a region spanning six residues from Ala21 to...
Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration
Jump to Section1. Introduction2. Materials and methods 2.1. Participants 2.2. Clinical and genetic assessment 2.3. Image acquisition 2.4. Image processing and creation of atrophy scores 2.5. Calculation of atrophy-based dementia risk score 2.6. Analysis3. Results 3.1. Participant demographics 3.2. Atrophy-based dementia risk...
Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Animal husbandry and ethics statementThe AB wild-type zebrafish (Danio rerio) was maintained in a fish breeding circulatory system (Haisheng, Shanghai, China) at 28 ± 0.5 °C with a 14 h light: 10 h dark cycle. The embryos were produced...
Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease...
Microglia contain Aβ aggregates in AD mouse models and humansThe aggregation of Aβ is an initial step in the formation of plaques, requiring an acidic pH13 and micromolar concentrations of Aβ monomers14. The extracellular...
