Effects of Galantamine Versus Donepezil on Sleep in Patients With Mild to Moderate Alzheimer...
Objective:
To examine the effects of galantamine and donepezil on patient and caregiver sleep.
Methods:
In this randomized, 8-week, double-blind, parallel-group, multicenter, pilot comparison of galantamine and donepezil, safety and efficacy data were collected. Objective...
Nonstroke Cardiovascular Disease and Risk of Alzheimer Disease and Dementia
Unresolved issues in dementia research include (1) the association between nonstroke cardiovascular disease (CVD) and Alzheimer disease (AD) and (2) whether the association between CVD and dementia is mediated by familial factors (ie, genes...
Cognitive and MRI trajectories for prediction of Alzheimer’s disease
Data setData were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (http://adni.loni.usc.edu). The ADNI was launched in 2003 as a public-private partnership, led by Principal Investigator Michael W. Weiner, MD, with an overall...
Autophagy regulation by acetylation—implications for neurodegenerative diseases
1.Mizushima, N. & Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147, 728–741 (2011).CAS
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Harry K. Genant, MD (1942-2021)
We are writing with the news that our long-time colleague, mentor, teacher, and friend Harry K. Genant, MD, passed away peacefully at his home in Napa on January 14.
Many of us...
Telling Stories of Challenges and Courage During Unprecedented Times
During challenging times, organizations like the Association of University Radiologists (AUR) encourage faculty and trainees to share and commemorate experiences. One such way was the AUR Storytelling Challenge, a joint...
Deep learning-Based 3D inpainting of brain MR images
1.Korolev, I. O., Symonds, L. L. & Bozoki, A. C. Predicting progression from mild cognitive impairment to Alzheimer’s dementia using clinical, MRI, and plasma biomarkers via probabilistic pattern classification. PLoS ONE 11, e0138866. https://doi.org/10.1371/journal.pone.0138866...
Cardiac and Blood Pressure Safety of Transdermal Rivastigmine in Elderly Patients With Dementia With...
Background:
Dementia with Lewy bodies (DLB) is the second most common dementia. Features of DLB include postganglionic cardiac sympathetic denervation and autonomic instability. Rivastigmine therapy, an acetylcholinesterase inhibitor, is widely used in the primary...
Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic...
1.Kametani, F. & Hasegawa, M. Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer’s disease. Front. Neurosci. 12, 25–35 (2018).Article
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AI-Enabled Portable X-Ray Device Shows Promise in the Clinical Environment
The UC San Francisco Department of Radiology and Biomedical Imaging noted a significant milestone for both the department and the UCSF Center for Intelligent Imaging (ci2) - full deployment of...
Latest article
Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...