Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes
1.Liu, J. Z., Erlich, Y. & Pickrell, J. K. Case-control association mapping by proxy using family history of disease. Nat. Genet. 49, 325–331 (2017).CAS
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In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of...
Percepta is the most effective reducer of brain Aβ 1–42 plaque fibrils in comparison to 20 other major memory-support dietary supplementsThioflavin T fluorometry quantitated, differentiated and compared the effects of different major memory-support dietary...
The Rest-Activity Rhythm and Physical Activity in Early-Onset Dementia
Background:
A substantial part of elderly persons with dementia show rest-activity rhythm disturbances. The rest-activity rhythm is important to study in people with early-onset dementia (EOD) for rest-activity rhythm disturbances are predictive of institutionalization,...
How do our memories take shape? — ScienceDaily
Your brain is constantly evaluating which aspects of your experiences to either remember for later, ignore, or forget. Dartmouth researchers have developed a new approach for studying these aspects of memory, by creating a...
Infection in dementia and delirium in frailty
In this issue of Nature Aging, Janbek et al. report results of a registry-based cohort study in Denmark...
Mitochondrial ubiquitin ligase alleviates Alzheimer’s disease pathology via blocking the toxic amyloid-β oligomer generation
Reagents and antibodiesAnti-MITOL rabbit polyclonal antibody was described previously14. Anti-APP C-terminal, anti-α-tubulin, and anti-β-actin antibodies were from Sigma. Anti-Aβ (D54D2), anti-synaptophysin, and anti-presenilin 1 (PS1) antibodies were from Cell Signaling. Anti-normal mouse IgG and...
Dementia identified as a risk factor for infection-related hospital contacts in a national, population-based...
1.Rao, A., Suliman, A., Vuik, S., Aylin, P. & Darzi, A. Outcomes of dementia: systematic review and meta-analysis of hospital administrative database studies. Arch. Gerontol. Geriatr. 66, 198–204 (2016).PubMed
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As you look around, mental images bounce between right and left brain — ScienceDaily
Ask anyone from an NFL quarterback scanning the field for open receivers, to an air traffic controller monitoring the positions of planes, to a mom watching her kids run around at the park: We...
Study used videos of realistic activities to measure how memory works day to day...
You might remember you ate cereal for breakfast but forget the color of the bowl. Or recall watching your partner put the milk away but can't remember on which shelf.
A new Northwestern Medicine study...
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Take it from the rats: A junk food diet can cause long-term damage to...
A new USC-led study on rats that feasted on a high-fat, sugary diet raises the possibility that a junk food-filled diet in teens may...
Repurposing non-pharmacological interventions for Alzheimer’s disease through link prediction on biomedical literature
The complete workflow is depicted in Fig. 1. To investigate the association between NPIs and AD, we initially conducted preprocessing and integration of biomedical triples...
Degenerative Dementias and Their Medical Care in the Movies
Compared with other neurologic problems, few films have been dedicated to degenerative dementia. To our knowledge, this is the first systematic review about the...