Newswise — Bristol scientists have discovered a novel pathology that occurs in several human neurodegenerative diseases, including Huntington’s disease.
The article, published in Brain Pathology, describes how SAFB1 expression occurs in both spinocerebellar ataxias and Huntington’s disease and may be a common marker of these conditions, which have a similar genetic background.
SAFB1 is an important protein controlling gene regulation in the brain and is similar in structure to other proteins associated with neurodegenerative diseases of age. The team, from the University of Bristol’s Translational Health Sciences, wanted to find out if this protein might be associated with certain neurodegenerative conditions.
The researchers analysed SAFB1 expression in the post-mortem brain tissue of spinocerebellar ataxias (SCA’s), Huntington’s disease (HD), Multiple…
