Tau can quickly spread between neurons but is not immediately harmful, according to research in mouse neurons published in JNeurosci. Intervening during the initial accumulation of tau could potentially halt the progression of Alzheimer’s disease.
A hallmark of Alzheimer’s disease is the accumulation of tau protein in neurons, which leads to their death. A diseased version of tau folds itself incorrectly, which leads to the buildup. Researchers did not know the timescale of this process and how misfolded tau can spread to other cells.
Hallinan et al. introduced diseased tau into mouse neurons…
