Connecting interferon, neuroinflammation and synapse loss in Alzheimer’s disease

Connecting interferon, neuroinflammation and synapse loss in Alzheimer's disease
Microscopic images reveal that microglia become activated (green) in response to certain types of toxic amyloid plaques (blue) and damage neurons (gold), leading to defects in learning and memory. Credit: Ethan Roy/ Hui Zheng lab

When immunologist Dr. Wei Cao joined Baylor College of Medicine three-and-a-half years ago, her first project was to investigate how inflammation contributes to Alzheimer’s disease.

“Alzheimer’s is the most common cause of dementia among older adults. The current understanding is that, in addition to having and tau protein tangles, the brains of patients with this condition have a marked inflammatory response, and that this inflammation might be more of a…

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