Study population
The JPSC-AD Study was a multisite, population-based, prospective, cohort study of dementia involving eight sites in Japan with a pre-specified protocol and standardized measurement methods across the research sites19,20,21,22. The study was conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The Medical Ethics Review Board of Ehime University (approval number 1610004) and Kyushu University Institutional Review Board for clinical research (approval number 686-10) approved this study. Written, informed consent was obtained from all participants. This study was performed in accordance with the Declaration of Helsinki. A total of 11,957 people consented to participate in the study between 2016 and 2018, of which 10,085 were eligible for the present study, excluding 547 participants younger than…
