Participants
The study included participants in the Mayo Clinic Study of Aging (MCSA), a longitudinal cohort study of individuals residing in Olmsted County, Minnesota, or in the Mayo Alzheimer’s Disease Research Center (ADRC), a longitudinal study of patients enrolled through the clinical practice. For inclusion in the study, all participants were required to have complete demographic information of sex and education, have at least one PET (amyloid or tau) and one MRI performed after 2009, and be age 50 years or older at the time of PET scan. MCSA participants were required to have a diagnosis of cognitively unimpaired (CU), mild cognitive impairment (MCI), or Alzheimer’s clinical syndrome dementia (AlzCS Dem) at their most recent visit, and ADRC participants a diagnosis of AlzCS Dem. The clinical diagnosis was determined by an expert panel utilizing established criteria and…
