Human samples
This research employed de-identified whole blood, plasma, and frozen and formalin fixed brain tissue from the biobank of the Alzheimer’s Disease Research Center at the University of Kentucky (UK-ADRC) under a protocol approved by the University of Kentucky Institutional Review Board (IRB). Informed consent was obtained prospectively. Whole blood samples were collected from 83 participants in a cohort spanning the cognitive continuum from cognitively unimpaired to mild cognitive impairment and dementia and 80 samples were analyzed (all included on the same amylin ELISA kit). Measurements were performed in duplicate. Frozen temporal cortex tissue samples were obtained from 42 persons with sAD-type dementia documented by amyloid β (Aβ) positivity and 18 cognitively unimpaired individuals. Both plasma and frozen brain tissue were obtained from 20 individuals. Formalin…
