Between the time you read the Wi-Fi password off the café’s menu board and the time you can get back to your laptop to enter it, you have to hold it in mind. If you’ve ever wondered how your brain does that, you are asking a question about working memory that has researchers have strived for decades to explain. Now MIT neuroscientists have published a key new insight to explain how it works.
In a study in PLOS Computational Biology, scientists at The Picower Institute for Learning and Memory compared measurements of brain cell activity in an animal performing a working memory task with the output of various computer models representing two theories of the underlying mechanism for holding information in mind. The results strongly favored the newer notion that a network of neurons stores the information by making short-lived changes in the pattern of their connections, or synapses,…