Predicting real world spatial disorientation in Alzheimer’s disease patients using virtual reality navigation tests

Participant recruitment

A total of 16 community residing AD patients as well as 21 age and gender-matched healthy controls were recruited for this study (see Supplementary Material for details on recruitment). All patients were clinically diagnosed with AD using the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association (NINCDS/ADRDA) diagnostic criteria23.

All recruited participants underwent an initial telephone screening procedure to assess their eligibility for the study. Inclusion criteria was being between 50 and 80 years of age, residing at home, and if in the patient group, having a clinical diagnosis for AD and a family carer (relative/spouse) that knows them well and is willing to assist in the study. The exclusion criteria was having a previous history of alcohol/substance abuse, diagnosis of…

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