Human tissue
Ascending aortic tissue samples were obtained from patients undergoing elective aneurysmal repair at Liverpool Heart and Chest Hospital (Supplementary Table 1). This study was ethically approved by Liverpool Bio-Innovation Hub (project approval reference 15-06 and 18-07), and informed consent was obtained for all participants. The LBIH Biobank confers ethical approval for the use of samples through their ethical approval as a Research Tissue Bank (REC reference 14/NW/1212, NRES Committee North West–Haydock). After collection, samples were rapidly frozen in dry ice and isopentane slurry, and immediately stored at –80 °C prior to use.
Human brain tissue (Supplementary Table 1) was obtained from the Queen Square Brain Bank for Neurological Disorders (UCL Institute of Neurology, London, UK; approval protocol no. EXTMTA5/16) and the Emory University Alzheimer’s Disease…
