Senescence biomarkers in whole blood
PD patients had significantly lower number of mitochondria (Est. = 62.74, SE = 27.02, df = 1, t = 2.36, p = 0.020, Fig. 1A,) with no significant effect of age (Est. = − 1.506, SE = 1.764, df = 115, t = − 0.857, p = 0.395) and sex (Est. = − 9.237, SE = 16.42, df = 1, t = − 0.56, p = 0.576). Our results show that PD patients had significantly longer telomeres in blood compared to controls (Est. = − 0.393, SE = 0.176, df = 1, t = − 2.23, p = 0.028, Fig. 1B), with no effect of age (Est. = 0.009, SE = 0.011, df = 115, t = 0.84, p = 0.400) and sex (Est. = 0.188, SE = 0.107, df = 1, t = 1.75, p = 0.083). Overall PD patients had 19.7% lower mtDNA copy number and 26.3% longer telomeres compared…
