Stopping dementia in Down syndrome patients

Stopping dementia in Down syndrome patients
Karyotype analysis of the iPSC clones. Credit: DOI: 10.1038/s41598-021-96697-7

Down syndrome is mostly known for the learning disabilities it causes, but patients typically suffer from a wide number of ailments. One is the early onset of Alzheimer’s disease. Using iPS cells from Down syndrome patients, a new study by CiRA researchers suggests that the molecular signs of Alzheimer’s disease result from higher oxidative stress in neurons and that antioxidants could have therapeutic effects.

Healthy individuals have 23 pairs of chromosomes, with one chromosome in each pair inherited from the mother and the other from the father. Down is caused by trisomy…

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