Restoring ‘chaperone’ protein may prevent plaque build-up in Alzheimer’s

Restoring “chaperone” protein may prevent plaque build-up in Alzheimer’s
DAXX (red color at top) prevents the aggregation of mutant p53 protein associated with cancers (dark green color at bottom) in cells. Credit: Perelman School of Medicine at the University of Pennsylvania

For the first time, Penn Medicine researchers showed how restoring levels of the protein DAXX and a large group of similar proteins prevents the misfolding of the rogue proteins known to drive Alzheimer’s and other neurodegenerative diseases, as well as certain mutations that contribute to cancers. The findings could lead to new targeted approaches that would restore a biological system designed to keep key proteins in check and prevent diseases.

The findings…

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