In lab tests, Imperial researchers have created a metal-based molecule that inhibits the build-up of a peptide associated with Alzheimer’s disease.
A peptide is a fragment of a protein, and one of the key hallmarks of Alzheimer’s disease is the build-up of a specific peptide known as amyloid-β. The team demonstrated that with the aid of ultrasound, their molecule can cross the blood-brain barrier in mice, targeting the part of the brain where the damaging peptide most often accumulates.
Alzheimer’s disease is the most common form of dementia, affecting approximately 50 million people worldwide. There is a pressing need to develop drugs that can prevent or reverse the effects of this devastating disease.
Some metal-based molecules have been previously designed to prevent amyloid-β from building up. However, these are often toxic to cells, or are unable to cross the blood-brain…
