ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease

Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239–259 (1991).

CAS 
PubMed 
PubMed Central 

Google Scholar 

Wischik, C. M. et al. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc. Natl Acad. Sci. USA 85, 4506–4510 (1988).

CAS 
PubMed 
PubMed Central 

Google Scholar 

Grundke-Iqbal, I. et al. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl Acad. Sci. USA 83, 4913–4917 (1986).

CAS 
PubMed 
PubMed Central 

Google Scholar 

Whitwell, J. L. et al. Neuroimaging correlates of pathologically defined subtypes of Alzheimer’s disease: a…