Aluminum is intricately associated with the neuropathology of familial Alzheimer’s disease

Aluminum is intricately associated with the neuropathology of familial Alzheimer's disease
Aluminum (orange) in a neuron in a donor’s brain tissue with familial Alzheimer’s disease. The same neuron revealed positive immunostaining (brown) for phosphorylated tau (pTau). Merging these images showed that aluminum and pTau are co-located inside the same cell. Credit: Dr. Mold

A new study builds upon two earlier published studies (Mold et al., 2020, Journal of Alzheimer’s Disease Reports) from the same group. The new data, also published in the Journal of Alzheimer’s Disease Reports, demonstrate that aluminum is co-located with phosphorylated tau protein, present as tangles within neurons in the brains of early-onset or familial Alzheimer’s disease (AD). “The presence of these tangles is associated with neuronal cell death, and observations of aluminum in these tangles may…

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