Early accumulation of tau in the brain predicts memory decline in Alzheimer’s disease

Early accumulation of tau in the brain predicts memory decline in Alzheimer’s disease
High accumulation of tau in the brain measured by a PET scanner was the only biomarker that could predict cognitive decline in healthy individuals, people with mild cognitive impairment and people with Alzheimer’s dementia. People with high tau levels in the brain also had high levels of amyloid plaques, while people with high levels of amyloid plaques did not necessarily have high tau levels. Credit: Marco Bucci

Researchers at Karolinska Institutet in Sweden have compared how well different Alzheimer’s biomarkers predict the progression of the disease and its effect on the memory. They found that early accumulation of tau proteins in the brain as measured by PET scanner was more effective at predicting memory impairment than biomarkers in the cerebrospinal fluid or amyloid plaque in…

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