Signal coupling between neuron-glia supernetwork may lead to improved memory formation

Signal coupling between neuron-glia super-network may lead to improved memory formation
Optogenetic control of glial pH suppresses or enhances the glial release of glutamate. Credit: Ko Matsui

Tohoku University scientists have shown that neuronal and glial circuits form a loosely coupled super-network within the brain. Activation of the metabotropic glutamate receptors in neurons was shown to be largely influenced by the state of the glial cells. Therefore, artificial control of the glial state could potentially be used to enhance the memory function of the brain.

The findings were detailed in the Journal of Physiology.

Although the glial occupy more than half of the , they were thought to act as glue—merely filling the gap between…

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