An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

  • 1.

    World Alzheimer Report 2015 (Alzheimer’s Disease International, 2015); https://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf

  • 2.

    Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet. Med. 18, 421–430 (2016).

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 3.

    Cummings, J. Lessons learned from Alzheimer disease: clinical trials with negative outcomes. Clin. Transl. Sci. 11, 147–152 (2018).

    PubMed 
    Article 
    PubMed Central 

    Google Scholar
     

  • 4.

    Mehta, D., Jackson, R., Paul, G., Shi, J. & Sabbagh, M. Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010–2015. Expert Opin. Investig. Drugs 26, 735–739 (2017).

    CAS 
    PubMed 
    PubMed…

  • Read more…