Researchers discover new pathway in TDP-43 related dementias

Researchers discover new pathway in TDP-43 related dementias
Maj-Linda Selenica outside of UK Sanders-Brown Center on Aging. Credit: Pete Comparoni | UK photo

Recent work published by researchers at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) highlights what the lead investigator calls the ‘cornerstone’ of her lab. Maj-Linda Selenica, assistant professor at SBCoA, led the study recently published in BBA Molecular Basis of Disease. She says their approach was unconventional as it looked at the molecular mechanisms implicated in TDP-43 biology, which is the focus of her lab.

TDP-43 is a DNA/RNA binding protein that has been found to be the hallmark in a wide range of neurodegenerative…

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