Leveraging preclinical models for the development of Alzheimer disease therapeutics

  • 1.

    van der Worp, H. B. et al. Can animal models of disease reliably inform human studies? PLoS Med. 7, e1000245 (2010).

  • 2.

    DeVita, V. T. Jr & Chu, E. A history of cancer chemotherapy. Cancer Res. 68, 8643–8653 (2008).

  • 3.

    Alzheimer’s Disease International. World Alzheimer Report 2018 (Alzheimer’s Disease International, 2018).

  • 4.

    Hippius, H. & Neundorfer, G. The discovery of Alzheimer’s disease. Dialogues Clin. Neurosci. 5, 101–108 (2003).

  • 5.

    Selkoe, D. J. & Hardy, J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol. Med. 8, 595–608 (2016).

  • 6.

    Karran, E. & De Strooper, B. The amyloid cascade hypothesis: are we poised for success or failure? J. Neurochem. 139, 237–252 (2016).

  • 7.

    Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet. Med. 18, 421–430 (2016).

  • 8.

    Bertram, L.,…

  • Read more…