Inflammation triggers fatal cycle in Alzheimer’s disease

Inflammation triggers fatal cycle in Alzheimer's disease
Inflammatory proteins (so-called ASC specks, red) in the nucleus of an accumulation of amyloid beta peptides (blue). Furthermore, immune cells (green) are shown. Computer visualization based on microscopic image data. Credit: Dario Tejera/Uni Bonn

An immune reaction in the brain seems to play a major role in the development of Alzheimer’s disease. In a way, it “adds fuel to the fire” and apparently causes an inflammation that, in a sense, keeps kindling itself. The study has now been published in the journal Cell Reports.

Alzheimer’s is characterized by clumps of the protein Aß (), which form large plaques in the . Aß resembles molecules on the surface of some bacteria. Over…

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