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Newswise — Researchers from the University of Illinois at Chicago have discovered that endothelial cells — those that create the inner lining of blood vessels — have unique genetic signatures based on their location in the body.
Their study, which is published in the journal eLife, used a genetic mouse model to compare endothelial cells in their natural organ environment. The researchers first looked at healthy mice and compared how genes were expressed in endothelial cells from heart, lung and brain tissues. Next, they studied the blood vessel endothelial cells of unhealthy mice — those exposed to a bacterial toxin, which mimicked inflammation in the whole body.
Under both conditions, endothelial cells from various organs…
