Study design
This study was a sub-analysis of our previously published, single-centre observational study (Gimlet study)5. The aim of this study was to investigate the association between the gut microbiome and MCI in patients without dementia. This study complied with the Declaration of Helsinki and was approved by the Institutional Review Board at the National Center for Geriatrics and Gerontology (No. 1191). Informed consent was obtained from all patients and their families before participation in this study. The Gimlet study is registered with the UMIN Clinical Trials Registry (UMIN000031851). Detailed information has been provided in the supplementary file and in the previous report5.
Subjects
Patients were eligible for the Gimlet study if they met the following criteria: (1) were able to undergo a brain MRI; (2) provided informed consent in writing; (3) provided informed consent…
