Study examines HIV drug’s potential to treat Alzheimer’s

Study examines HIV drug's potential to treat Alzheimer's
CYP46A1 is an endoplasmic reticulum cytochrome P450 enzyme, which is expressed in the central nervous system, normally in the soma and dendrites of multiple neuron types. Credit: Journal of Medicinal Chemistry (2019). DOI: 10.1021/acs.jmedchem.9b01383

A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer’s disease, and Vanderbilt University biochemist F. Peter Guengerich, Ph.D., is aiding efforts to make this approach to improving memory and cognitive function even better.

Last month in the Journal of Medicinal Chemistry, Guengerich and colleagues at Case Western Reserve University School of Medicine in Cleveland, Ohio, reported that structural modifications…

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