Study populations
Individuals with MCI from ADNI and mild cognitive symptoms (MCS) from BioFINDER were included in the retrospective analyses, based on the following criteria: availability of a baseline Mini-Mental State Examination (MMSE) score; a baseline CSF sample; and a valid baseline measurement of the Elecsys biomarkers Aβ(1–42), pTau and tTau.
ADNI
ADNI is an ongoing, longitudinal, multicentre study of volunteers with MCI or early AD, as well as cognitively normal healthy individuals enrolled at over 50 clinical centres, which started in 2004. Definitions of the participant classifications are presented below.
Normal cognition: MMSE scores between 24 and 30 (inclusive), a Clinical Dementia Rating (CDR) of 0, non-depressed, non-MCI and non-demented.
MCI: MMSE scores between 24 and 30 (inclusive), a memory complaint, have objective memory loss measured by education-adjusted scores…
