Neurological diseases such as Alzheimer’s disease are characterised by aggregates of protein in the brain. The connection of these aggregates to the disease itself is unclear. Martina Huber, Enrico Zurlo and colleagues published a new method to monitor the formation of these aggregates.
While they are clumping together, the proteins first form aggregates of several molecules, named oligomers. These may aggregate further, until they form the large aggregates or plaques, that have been found in the brains of people with Alzheimer’s disease.
“For a long time, it has been thought that these plaques cause the brain damage, but more and more evidence suggests that it may be the…
